2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0155041 sodium

VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).

For research use only. We do not sell to patients.

VU0155041 sodium Chemical Structure

VU0155041 sodium Chemical Structure

CAS No. : 1259372-69-4

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VU0155041 sodium Related Antibodies

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Description

VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)[1].

IC50 & Target[1]

mGluR4

693 nM (EC50)

In Vitro

VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU0155041 sodium Related Antibodies
In Vivo

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
Dosage: 31, 93 nmol
Administration: I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
Result: Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.
Molecular Weight

338.16

Formula

C14H14Cl2NNaO3
CAS No.
SMILES

O=C([C@H](CCCC1)[C@H]1C(O[Na])=O)NC2=CC(Cl)=CC(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU0155041 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU01550411259372-69-4VU 0155041VU-0155041mGluRMetabotropic glutamate receptorsmGluR4partial glutamateInhibitorinhibitorinhibit

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