2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0360172 hydrochloride

VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice.

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VU0360172 hydrochloride Chemical Structure

VU0360172 hydrochloride Chemical Structure

CAS No. : 1309976-62-2

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VU0360172 hydrochloride Related Antibodies

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Description

VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

IC50 & Target[1]

mGluR5

16 nM (EC50)

mGluR5

195 nM (Ki)

Molecular Weight

330.78

Formula

C18H16ClFN2O
CAS No.
SMILES

O=C(C1=CN=C(C=C1)C#CC2=CC(F)=CC=C2)NC3CCC3.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU0360172 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU03601721309976-62-2VU 0360172VU-0360172mGluRMetabotropic glutamate receptorsmGlu5 receptorpositive allosteric modulatorpolyphosphoinositideInhibitorinhibitorinhibit

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