2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0486321

VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

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VU0486321 Chemical Structure

VU0486321 Chemical Structure

CAS No. : 1816301-67-3

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Based on 1 publication(s) in Google Scholar

VU0486321 Related Antibodies

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Description

VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
31.8 nM
Compound: 17e
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
[PMID: 26426481]
Molecular Weight

398.77

Formula

C20H12ClFN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C2C(C(N(C2=O)C3=CC=C(C=C3Cl)NC(C4=C(C=CO4)C)=O)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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VU0486321 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU04863211816301-67-3VU 0486321VU-0486321mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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