2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0486321

VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

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VU0486321 Chemical Structure

VU0486321 Chemical Structure

CAS No. : 1816301-67-3

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Based on 1 publication(s) in Google Scholar

VU0486321 Related Antibodies

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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Description

VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
31.8 nM
Compound: 17e
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
[PMID: 26426481]
Molecular Weight

398.77

Formula

C20H12ClFN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C2C(C(N(C2=O)C3=CC=C(C=C3Cl)NC(C4=C(C=CO4)C)=O)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.30%

Data Sheet (268 KB) SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References
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VU0486321 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

VU04863211816301-67-3VU 0486321VU-0486321mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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