In this Webinar, you will learn:
• How innate immune receptors regulate inflammation and activate inflammasome in infectious diseases
• The role of innate immune receptors in controlling tumors development
• The functions of innate immune system in maintaining health and combating disease
About this Webinar:
Inflammation is a vital process that protects us from infections. Excessive or prolonged inflammation, however, can contribute to serious health issues, including cancer. In this webinar, Dr. Si Ming Man will present their recent findings on the role of innate immune receptors in controlling inflammation and inflammasome activation, shedding light on their impact in infectious diseases. He will also explore how these innate immune receptors influence tumor development, with many acting independently of well-known inflammatory pathways through mechanisms such as DNA-damage response. These insights open up new avenues for therapeutic strategies targeting both infections and cancer.
The webinar record will be shared to the registrants.
Webinar certificate is available. (Please send the request to: Marketing@medchemexpress.com)
About Si Ming Man, PhD
Dr. Si Ming Man is a leading researcher in the fields of immunology, infection, and cancer. Currently, he holds the positions of Professor, CSL Centenary Fellow, and NHMRC Leadership Fellow at the Australian National University. His research focuses on how the innate immune defends against infectious diseases and how dysregulated inflammation can drive cancer progression. Dr. Man's innovative contributions have been earned him prestigious recognitions, including the Frank Fenner Prize for Life Scientist of the Year (2022) and the Australian Academy of Science Gottschalk Medal (2023). His work has also been highlighted by several Clarivate™ Highly Cited Researcher awards.
https://researchportalplus.anu.edu.au/en/persons/si-ming-man
Recent Publications:
[1] Man, S.M*., Karki, R*., Sasai, M., Place, D.E., Kesavardhana, S., Temirov, J., Frase, S., Zhu, Q., Malireddi, R.K.S., Kuriakose, T., Peters, J.L., Neale, G., Brown, S.A., Yamamoto, M., Kanneganti, T.D. (2016) IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11–NLRP3 inflammasomes. Cell. 167:382–396. *Co-first author. [Content Brief]
[2] Man, S.M*., Zhu, Q*., Zhu, L*., Liu, Z*., Karki, R., Malik, A., Sharma, D., Li, L., Malireddi, R.K.S., Gurung, P., Neale, G., Olsen, S.R., Carter, R.A., McGoldrick, D.J., Wu, G., Finkelstein, D., Vogel, P., Gilbertson, R.J., Kanneganti, T.D. (2015) Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer. Cell. 162:45-58. *Co-first author. [Content Brief]
[3] Karki, R*., Man, S.M*., Malireddi, R.K.S., Kesavardhana, S., Zhu, Q., Burton, A.R., Sharma, B.R., Pelletier, S., Vogel, P., Rosenstiel, P., Kanneganti, T.D. (2016) NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer. Nature. 540:583–587. *Co-first author. [Content Brief]
[4] Man, S.M., Karki, R., Malireddi, R.K.S., Neale, G., Vogel, P., Yamamoto, M., Lamkanfi, M., Kanneganti, T.D. (2015) The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection. Nature Immunology. 16:467–475. [Content Brief]
[5] Jing, W., Lo Pilato, J., Kay, C., Feng, S., Enosi Tuipulotu, D., Mathur, A., Shen, C., Ngo, C., Zhao, A., Miosge, L.A., Ali, S.A., Gardiner, E.E., Awad, M.M., Lyras, D., Robertson, A.A.B., Kaakoush, N.O., Man, S.M. (2022) Clostridium septicum alpha-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins. Science Immunology. 7:eabm1803. ‡ Senior author. [Content Brief]
