2. Stem Cell/Wnt Apoptosis
  3. Wnt β-catenin MDM-2/p53
  4. Wnt/β-catenin-IN-3

Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells.

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Wnt/β-catenin-IN-3 Chemical Structure

Wnt/β-catenin-IN-3 Chemical Structure

CAS No. : 1809413-98-6

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Wnt/β-catenin-IN-3 Related Antibodies

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Description

Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells[1].

In Vitro

Wnt/β-catenin-IN-3 (0.5-2 μM, 48 h) induces apoptosis in HCT116 cells in a dose-dependent manner and causes G2/M cell cycle arrest though activation of p53-p21 pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Wnt/β-catenin-IN-3 Related Antibodies
Molecular Weight

461.46

Formula

C26H23NO7
CAS No.
SMILES

COC1=CC=C(C=C1)C(NC2=CC(C3=CC(C4=C(C(OC)=C(C=C4O3)OC)OC)=O)=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Wnt/β-catenin-IN-3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Wnt/β-catenin-IN-31809413-98-6Wntβ-cateninMDM-2/p53Beta cateninWnt/β-CateninG2/MarrestapoptosisInhibitorinhibitorinhibit

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