WR99210 hydrochloride (Synonyms: BRL 6231)

Cat. No.: HY-116387A: FAQs
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WR99210 hydrochloride is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC₅₀<0.075 nM). WR99210 hydrochloride shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains as well as T. gondii.

For research use only. We do not sell to patients.

WR99210 hydrochloride Chemical Structure

CAS No. : 30711-93-4

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Other Forms of WR99210 hydrochloride:

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2 Publications Citing Use of MCE WR99210 hydrochloride

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Purity & Documentation
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Description	WR99210 hydrochloride is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC₅₀<0.075 nM). WR99210 hydrochloride shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains as well as T. gondii^[1]^[2]^[3].
Molecular Weight	431.14
Formula	C₁₄H₁₉Cl₄N₅O₂
CAS No.	30711-93-4
SMILES	CC1(N=C(N=C(N1OCCCOC2=C(C=C(C(Cl)=C2)Cl)Cl)N)N)C.[H]Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. [Content Brief] [2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41. [Content Brief] [3]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. [Content Brief]

WR99210 hydrochloride Related Classifications

Infection

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WR9921030711-93-4BRL 6231WR 99210WR-99210BRL6231BRL-6231Dihydrofolate reductase (DHFR)ParasiteP. falciparumparasitetoxoplasma gondiiT. gondiiInhibitorinhibitorinhibit

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