2. GPCR/G Protein
  3. Formyl Peptide Receptor (FPR)
  4. WRW4 TFA

WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide.

For research use only. We do not sell to patients.

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WRW4 TFA Chemical Structure

WRW4 TFA Chemical Structure

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WRW4 TFA Related Antibodies

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Description

WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].

In Vitro

WRW4 TFA inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 TFA specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WRW4 TFA Related Antibodies
Molecular Weight

1218.29

Formula

C63H66F3N15O8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WRW4 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WRW4WRW 4WRW-4Formyl Peptide Receptor (FPR)Inhibitorinhibitorinhibit

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