2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Xanthine oxidase-IN-14

Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC50 >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC50 greater than 150 μM.

For research use only. We do not sell to patients.

Xanthine oxidase-IN-14 Chemical Structure

Xanthine oxidase-IN-14 Chemical Structure

CAS No. : 80025-67-8

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Xanthine oxidase-IN-14 Related Antibodies

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Description

Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC50 >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC50 greater than 150 μM[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 GI50
> 150 μM
Compound: 3f
Growth inhibition of human MCF7 cells after 48 hrs
Growth inhibition of human MCF7 cells after 48 hrs
[PMID: 17692432]
NCI-H460 GI50
> 150 μM
Compound: 3f
Growth inhibition of human NCI-H460 cells after 48 hrs
Growth inhibition of human NCI-H460 cells after 48 hrs
[PMID: 17692432]
SF-268 GI50
> 150 μM
Compound: 3f
Growth inhibition of human SF268 cells after 48 hrs
Growth inhibition of human SF268 cells after 48 hrs
[PMID: 17692432]
Molecular Weight

252.20

Formula

C11H7F3N4
CAS No.
SMILES

N#CC1=C(N)N(C2=CC=C(C(F)(F)F)C=C2)N=C1
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References
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Xanthine oxidase-IN-14 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthine oxidase-IN-1480025-67-8Xanthine OxidaseXOMCF-7NCI-H460SF-268Inhibitorinhibitorinhibit

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