XSJ-10

Cat. No.: HY-157740: FAQs
Data Sheet Handling Instructions

Molarity Calculator

XSJ-10 is a HDAC inhibitor containing a RAS/RAF protein interfering unit, with IC_{50_s} of 0.05 and 0.04 μM in PANC-1 cells and HT-29 cells. XSJ-10 can effectively induce the apoptosis of cancer cells and suppress the tumor by strongly inhibiting the RAS-RAF-MEK-ERK signaling pathway and the acetylation level of HDAC3.

For research use only. We do not sell to patients.

XSJ-10 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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•Related Small Molecules:

•Related Proteins:

View All HDAC Isoform Specific Products:

View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

HDAC1

11.37 nM (IC₅₀)

HDAC2

9.97 nM (IC₅₀)

HDAC3

8.97 nM (IC₅₀)

HDAC8

88.64 nM (IC₅₀)

HDAC4

75.05 nM (IC₅₀)

HDAC5

75.14 nM (IC₅₀)

HDAC7

121.28 nM (IC₅₀)

HDAC9

83.67 nM (IC₅₀)

HDAC6

67.04 nM (IC₅₀)

HDAC10

77.55 nM (IC₅₀)

HDAC11

72.54 nM (IC₅₀)

Molecular Weight

466.50

Formula

C₂₁H₂₆N₂O₈S

SMILES

COC1=CC(OC)=C(C(OC)=C1)/C=C/S(CC2=CC=C(C(NCC(NO)=O)=C2)OC)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit. J Med Chem. 2024 Feb 8;67(3):2066-2082. [Content Brief]

XSJ-10 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XSJ-10XSJ10XSJ 10HDACHistone deacetylasesRASRAFcancerHDAC3PANC-1HT-29MEKERKInhibitorinhibitorinhibit

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