2. Stem Cell/Wnt
  3. YAP
  4. YAP-TEAD-IN-1

YAP-TEAD-IN-1 is a potent and competitive inhibitor of?YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM).

For research use only. We do not sell to patients.

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YAP-TEAD-IN-1 Chemical Structure

YAP-TEAD-IN-1 Chemical Structure

CAS No. : 1659305-78-8

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Based on 2 publication(s) in Google Scholar

Other Forms of YAP-TEAD-IN-1:

YAP-TEAD-IN-1 Related Antibodies

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Description

YAP-TEAD-IN-1 is a potent and competitive inhibitor of?YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].

IC50 & Target

IC50: 25 nM (YAP–TEAD interaction)[1]
In Vitro

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD (1209-426) in a GST pull-down assay, the Kd of His-YAP1209-426 is determined to be 40 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YAP-TEAD-IN-1 Related Antibodies
Molecular Weight

2019.86

Formula

C93H144ClN23O21S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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YAP-TEAD-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YAP-TEAD-IN-11659305-78-8YAPYes-associated proteinYAP–TEADinteractionpeptidePPIInhibitorinhibitorinhibit

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HY-P2244
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