2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis Deubiquitinase
  4. YCH3124

YCH3124 (compound Z33) is a USP7 inhibitor (IC50=41.9 nM) with antitumor activity. YCH3124 has good in vitro antiproliferative activity against various tumor cells including LNCaP (IC50=3.6 nM) and CHP-212 (IC50=9.9 nM). In addition, YCH3124 disrupts cell cycle progression by restricting G1 phase and induces apoptosis in CHP-212 cells.

For research use only. We do not sell to patients.

YCH3124 Chemical Structure

YCH3124 Chemical Structure

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YCH3124 Related Antibodies

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USP1 USP2 USP7 USP8 USP30 UCHL1

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Description

YCH3124 (compound Z33) is a USP7 inhibitor (IC50=41.9 nM) with antitumor activity. YCH3124 has good in vitro antiproliferative activity against various tumor cells including LNCaP (IC50=3.6 nM) and CHP-212 (IC50=9.9 nM). In addition, YCH3124 disrupts cell cycle progression by restricting G1 phase and induces apoptosis in CHP-212 cells[1].

IC50 & Target[1]

USP7

41.9 nM (IC50)

Molecular Weight

530.61

Formula

C30H34N4O5
SMILES

O=C1N(CC2(O)CCN(C(C[C@@H](C)C3=CC=CC=C3)=O)CC2)C=NC4=C1C=CN4C5=CC=C(OC)C(OC)=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YCH3124 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YCH3124YCH 3124YCH-3124ApoptosisDeubiquitinaseDUBsUSP7inhibitorantiproliferationapoptosisLNCaPCHP-212Inhibitorinhibit

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