2. Cell Cycle/DNA Damage PROTAC Epigenetics
  3. Ligands for E3 Ligase HDAC
  4. YF438

YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2.

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YF438 Chemical Structure

YF438 Chemical Structure

CAS No. : 2247210-09-7

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YF438 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2[1].

Molecular Weight

438.48

Formula

C23H26N4O5
CAS No.
SMILES

O=C(CCCCCC(NO)=O)N(CC1=NOC(C2=CC=CC=C2)=N1)C3=CC=C(OC)C=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YF438 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YF4382247210-09-7YF 438YF-438Ligands for E3 LigaseHDACE3 ligase-recruiting MoietyHistone deacetylasesTriple-negative breast cancer (TNBC)BALB/cInhibitorinhibitorinhibit

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