2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. YLIU-4-105-1

YLIU-4-105-1 is a Type II JAK2 inhibitor. YLIU-4-105-1 has in vivo pharmacodynamic activity as evidenced by inhibiting pSTAT5, reducing spleen to body weight, and lowering blood reticulocyte counts in a dose-dependent manner.

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YLIU-4-105-1 Chemical Structure

YLIU-4-105-1 Chemical Structure

CAS No. : 2417685-83-5

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YLIU-4-105-1 Related Antibodies

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Description

YLIU-4-105-1 is a Type II JAK2 inhibitor. YLIU-4-105-1 has in vivo pharmacodynamic activity as evidenced by inhibiting pSTAT5, reducing spleen to body weight, and lowering blood reticulocyte counts in a dose-dependent manner[1].

Molecular Weight

605.65

Formula

C32H34F3N7O2
CAS No.
SMILES

O=C(C1=CC(C2=NN3C=C(NC(C4CC4)=O)N=C3C=C2)=C(C)C=C1)NC5=CC(C(F)(F)F)=CC(CN6CCN(CC6)CC)=C5
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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YLIU-4-105-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YLIU-4-105-12417685-83-5JAKJanus kinasepSTAT5spleen to body weightblood reticulocyte countsInhibitorinhibitorinhibit

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