Z-Pro-prolinal  (Synonyms: N-Benzyloxycarbonyl-L-prolyl-L-prolinal)

Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC₅₀ of 0.4 nM for porcine PREP^[1][2][3].

IC₅₀: 0.4 nM (porcine PREP)^[2]
K_i: 3.7 nM (PREP from bovine brain)^[1]

Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) (100 mg/kg; p.o.; once) increases septal vasopressin content in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

330.38

C₁₈H₂₂N₂O₄

88795-32-8

O=C[C@H]1N(C([C@H]2N(C(OCC3=CC=CC=C3)=O)CCC2)=O)CCC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tsuru D, et al. Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase. J Biochem. 1988;104(4):580-586.  [Content Brief]

  [2]. Kilpeläinen TP, et al. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. Biomed Pharmacother. 2020;128:110253.  [Content Brief]

  [3]. Miura N, et al. Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats. Neurosci Lett. 1995;196(1-2):128-130.  [Content Brief]