ZC0101

Cat. No.: HY-147772: FAQs
Data Sheet Handling Instructions

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ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC₅₀ values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells.

For research use only. We do not sell to patients.

ZC0101 Chemical Structure

CAS No. : 2541604-52-6

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IDO1 IDO2 IDO

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IDO1

0.084 μM (IC₅₀)

TrxR

7.98 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.55 μM Compound: 41; ZC0101	Cytotoxicity against human HCT-116 incubated for 24 hrs by CCK-8 assay Cytotoxicity against human HCT-116 incubated for 24 hrs by CCK-8 assay	[PMID: 35696861]

In Vivo

ZC0101 (60 mg/kg; p.o.; once) effectively suppresses IDO1 activity in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

293.32

Formula

C₁₇H₁₅N₃O₂

CAS No.

2541604-52-6

SMILES

O=C1C=CCCN1C(/C=C/C2=CC=CC=C2C3=CNC=N3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fan QZ, et al. Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor. Bioorg Chem. 2020 Dec;105:104401. [Content Brief]

ZC0101 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZC01012541604-52-6ZC 0101ZC-0101Indoleamine 2,3-Dioxygenase (IDO)ApoptosisReactive Oxygen SpeciesantitumorHeLaHCT-116orally activelow cytotoxicityC57BL/6 miceInhibitorinhibitorinhibit

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