2. Cell Cycle/DNA Damage Epigenetics Vitamin D Related/Nuclear Receptor
  3. HDAC VD/VDR
  4. ZG-126

ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization.

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ZG-126 Chemical Structure

ZG-126 Chemical Structure

CAS No. : 3049802-32-3

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ZG-126 Related Antibodies

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Description

ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization[1].

IC50 & Target

HDAC6

0.633 μM (IC50)

HDAC3

0.997 μM (IC50)

HDAC11

2.02 μM (IC50)

HDAC1

2.53 μM (IC50)

HDAC8

3.31 μM (IC50)

HDAC2

4.64 μM (IC50)

HDAC10

13.9 μM (IC50)

HDAC7

55.4 μM (IC50)

HDAC5

59.4 μM (IC50)

HDAC4

67.6 μM (IC50)

Molecular Weight

513.67

Formula

C29H43N3O5
CAS No.
SMILES

CCC(CC)(C1=CC=C(C=C1)C(NCCCCC(NO)=O)=O)C2=NC(C)=C(C=C2)OCC(C(C)(C)C)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZG-126 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZG-1263049802-32-3ZG126ZG 126HDACVD/VDRHistone deacetylasesVitamin DVitamin D receptorC57BL/6 mouseB16-F10MDA-MB-2314T1panmelanomaTNBCInhibitorinhibitorinhibit

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