2. Cell Cycle/DNA Damage
  3. ClpP
  4. ZG36

ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model.

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ZG36 Chemical Structure

ZG36 Chemical Structure

CAS No. : 2999673-34-4

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ZG36 Related Antibodies

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Description

ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model[1].

Molecular Weight

607.54

Formula

C31H35BrN4O4
CAS No.
SMILES

BrC1=CC=C(CNC(N(CC2)[C@]3([H])N([C@H](C(N(C3)CC4=C5C(C=CC=C5)=C(OC)C=C4)=O)[C@H](CC)C)C2=O)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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ZG36 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZG362999673-34-4ZG 36ZG-36ClpPCaseinolytic protease PAMLcancerrespiratory chain complexesmitochondrial DNAInhibitorinhibitorinhibit

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