ZIKV-IN-3 

ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC₅₀ value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV)^[1].

IC50: 18.34 μM (MTase)^[1]

ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC₅₀ value of 0.76 μM and has anti-ZIKV effect with EC₅₀ values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively^[1].
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC₅₀ value of 0.38 μM and inhibits ZIKV replication and infection^[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells^[1]. Vero, Huh7 and A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

587.75

C₃₉H₄₁NO₄

947699-46-9

O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@@](COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)(C)/C(CC[C@@]23C)=N/O)=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710.  [Content Brief]