α-Amylase/α-Glucosidase-IN-4

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α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity.

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α-Amylase/α-Glucosidase-IN-4 Chemical Structure

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Description	α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity^[1].
IC₅₀ & Target	IC50: 0.15 μM (α-Glucosidase), 1.10 μM (α-Amylases)^[1]
Molecular Weight	654.58
Formula	C₃₂H₂₆N₆O₁₀
SMILES	O=C(OCC)C1=C(NC2=CC=C([N+]([O-])=O)C=C2)CC(N(C3=CC=C([N+]([O-])=O)C=C3)C1C4=CC=CC([N+]([O-])=O)=C4)C5=CC([N+]([O-])=O)=CC=C5
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Saleem F, et al. Multicomponent diastereoselective synthesis of tetrahydropyridines as α-amylase and α-glucosidase enzymes inhibitors. Future Med Chem. 2023 Aug 31.. . [Content Brief]