2. Neuronal Signaling
  3. Amyloid-β
  4. β-Amyloid (22-35) (TFA)

β-Amyloid (22-35) (TFA)  (Synonyms: Amyloid β-Protein (22-35) (TFA))

Cat. No.: HY-P1474A Purity: 96.48%
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β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).

For research use only. We do not sell to patients.

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β-Amyloid (22-35) (TFA) Chemical Structure

β-Amyloid (22-35) (TFA) Chemical Structure

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1 mg USD 70 In-stock
5 mg USD 280 In-stock
10 mg USD 480 In-stock
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100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of β-Amyloid (22-35) (TFA):

β-Amyloid (22-35) (TFA) Related Antibodies

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Description

β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution)[1].

In Vitro

β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA shows significant cytotoxicity on the rat hippocampal neurons at 40 μg/mL, but exhibits no cytotoxic effect on the glial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Amyloid (22-35) (TFA) Related Antibodies
Molecular Weight

1517.64

Formula

C61H103F3N16O23S
Appearance

Solid

Color

White to off-white

Sequence

Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
Sequence Shortening

EDVGSNKGAIIGLM
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (65.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6589 mL 3.2946 mL 6.5892 mL
5 mM 0.1318 mL 0.6589 mL 1.3178 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6589 mL 3.2946 mL 6.5892 mL 16.4729 mL
5 mM 0.1318 mL 0.6589 mL 1.3178 mL 3.2946 mL
10 mM 0.0659 mL 0.3295 mL 0.6589 mL 1.6473 mL
15 mM 0.0439 mL 0.2196 mL 0.4393 mL 1.0982 mL
20 mM 0.0329 mL 0.1647 mL 0.3295 mL 0.8236 mL
25 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.6589 mL
30 mM 0.0220 mL 0.1098 mL 0.2196 mL 0.5491 mL
40 mM 0.0165 mL 0.0824 mL 0.1647 mL 0.4118 mL
50 mM 0.0132 mL 0.0659 mL 0.1318 mL 0.3295 mL
60 mM 0.0110 mL 0.0549 mL 0.1098 mL 0.2745 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Amyloid (22-35) (TFA) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Amyloid (22-35) (TFA)Amyloid β-Protein (22-35) (TFA)Amyloid-ββ-amyloid peptideAβAbetaβ-amyloidcytotoxicneuronsrathippocampusaggregatesamyloidfibrilsInhibitorinhibitorinhibit

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