β-Chlornaltrexamine dihydrochloride (Synonyms: β-CNA dihydrochloride)

Cat. No.: HY-141468: FAQs
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β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception.

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β-Chlornaltrexamine dihydrochloride Chemical Structure

CAS No. : 67025-98-3

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Description	β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception^[1].
Molecular Weight	540.35
Formula	C₂₄H₃₄Cl₄N₂O₃
CAS No.	67025-98-3
SMILES	O[C@]1([C@H]2C3)[C@@]4(CCN2CC5CC5)C6=C3C=CC(O)=C6O[C@@]4([H])[C@H](N(CCCl)CCCl)CC1.[H]Cl.[H]Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Reichard K L, et al. Regulation of kappa opioid receptor inactivation depends on sex and cellular site of antagonist action[J]. Molecular Pharmacology, 2020, 98(5): 548-558. [Content Brief]

β-Chlornaltrexamine dihydrochloride Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Chlornaltrexamine67025-98-3β-CNAOpioid ReceptorDopamineopioid receptorblockerpain perceptionneurotransmittersInhibitorinhibitorinhibit

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β-Chlornaltrexamine dihydrochloride (Synonyms: β-CNA dihydrochloride)

β-Chlornaltrexamine dihydrochloride Related Antibodies

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