2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Drug-Linker Conjugates for ADC Apoptosis
  4. β-Glucuronide-dPBD-PEG5-NH2

β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity.

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β-Glucuronide-dPBD-PEG5-NH2 Chemical Structure

β-Glucuronide-dPBD-PEG5-NH2 Chemical Structure

CAS No. : 2246363-68-6

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Other Forms of β-Glucuronide-dPBD-PEG5-NH2:

β-Glucuronide-dPBD-PEG5-NH2 Related Antibodies

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity[1].

IC50 & Target

Drug-linker conjugates for ADC, Apoptosis[1]
Molecular Weight

1696.66

Formula

C78H101N7O35
CAS No.
SMILES

NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[C@](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[C@](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)C(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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β-Glucuronide-dPBD-PEG5-NH2 Related Classifications

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Keywords:

β-Glucuronide-dPBD-PEG5-NH22246363-68-6Drug-Linker Conjugates for ADCApoptosisβ-glucuronide-linked pyrrolobenzodiazepine dimerantibody-drug conjugateADCcIRCR201-dPBDcleavable linkerprodrugreduces side effectsInhibitorinhibitorinhibit

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