2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase Amyloid-β
  4. γ-Secretase modulator 12

γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice.

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γ-Secretase modulator 12 Chemical Structure

γ-Secretase modulator 12 Chemical Structure

CAS No. : 2204249-82-9

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Description

γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].

Molecular Weight

397.47

Formula

C25H23N3O2
CAS No.
SMILES

O=C1C2=C(CN1CC)C=C(C3=C(C)N=C4C(OCC5=CC=CC=C5)=CC=CN43)C=C2
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Room temperature in continental US; may vary elsewhere.
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γ-Secretase modulator 12 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Secretase modulator 122204249-82-9γ-secretaseAmyloid-βGamma secretaseβ-amyloid peptideAβAbetaγ-secretase modulatorAlzheimer’s diseaseamyloid-β42Inhibitorinhibitorinhibit

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