2. Apoptosis
  3. Apoptosis
  4. [1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol 

Cat. No.: HY-120654
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[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol (compound 13g) is a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. [1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol shows a potent apoptotic effect.

For research use only. We do not sell to patients.

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure

CAS No. : 890854-82-7

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[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Related Antibodies

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Description

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol (compound 13g) is a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. [1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol shows a potent apoptotic effect[1].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
7 μM
Compound: 14
Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method
Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method
[PMID: 19764793]
K562 IC50
20 μM
Compound: 14
Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method
Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method
[PMID: 19764793]
K562 IC50
20 μM
Compound: 1
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
[PMID: 25221651]
K562 IC50
75 μM
Compound: 14
Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay
Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay
[PMID: 19764793]
U373-MAGI EC50
8.8 μM
Compound: 6
Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
[PMID: 23010273]
Molecular Weight

278.30

Formula

C18H14O3
CAS No.
SMILES

OC1=CC=C(C2=CC=C(C3=CC(O)=CC(O)=C3)C=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol890854-82-7Apoptosisterphenyl derivativeG0-G1 phasedifferentiationapoptoticInhibitorinhibitorinhibit

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