1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₄  (Synonyms: 1,2-Distearoyl-sn-glycero-3-PC-d₄; DSPC-d₄)

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₄ is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

794.17

C₄₄H₈₄D₄NO₈P

326495-35-6

Solid

White to off-white

CCCCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCCCC)=O)COP(OC([2H])([2H])C([2H])([2H])[N+](C)(C)C)([O-])=O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.  [Content Brief]

  [2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739.  [Content Brief]

  [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.  [Content Brief]