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  4. 1-Acetyl-3-o-toluyl-5-fluorouracil

1-Acetyl-3-o-toluyl-5-fluorouracil  (Synonyms: A-​OT-​Fu)

Cat. No.: HY-U00130
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1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.

For research use only. We do not sell to patients.

1-Acetyl-3-o-toluyl-5-fluorouracil Chemical Structure

1-Acetyl-3-o-toluyl-5-fluorouracil Chemical Structure

CAS No. : 71861-76-2

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Description

1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.

In Vivo

Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

290.25

Formula

C14H11FN2O4
CAS No.
SMILES

O=C1N(C(C2=CC=CC=C2C)=O)C(C(F)=CN1C(C)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[1]

Mice: Of the ten groups of tumor bearing mice, subcutaneous administration of 5-fluorouracil or 1-Acetyl-3-o-toluyl-5-fluorouracil is made at a dose of 0.2, 0.4 and 0.6 mmol/kg/d on six groups in the buttock region. In three groups, oil solution of 1-Acetyl-3-o-toluyl-5-fluorouracil is administered orally with a stomach tube at a dose of 0.2, 0.4 and 0.6 mmol/kg/d. The remaining group is used as tumor bearing control. During the period of the experiment, body weight is measured every 3 day and the long and short diameters of the tumor are measured daily[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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1-Acetyl-3-o-toluyl-5-fluorouracil Related Classifications

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Keywords:

1-Acetyl-3-o-toluyl-5-fluorouracil71861-76-2A-​OT-​FuOthersInhibitorinhibitorinhibit

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