2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 1-Naphthol

1-Naphthol  (Synonyms: Furro ER; NSC 9586; Nako TRB)

Cat. No.: HY-Y1309 Purity: 99.90%
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1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media.

For research use only. We do not sell to patients.

1-Naphthol Chemical Structure

1-Naphthol Chemical Structure

CAS No. : 90-15-3

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Based on 1 publication(s) in Google Scholar

Other Forms of 1-Naphthol:

1-Naphthol Related Antibodies

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Description

1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
240 μM
Compound: 1-Naphthol
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
[PMID: 21030469]
HEK293 IC50
280 μM
Compound: 1-Naphthol
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
[PMID: 21030469]
K562 IC50
> 100 μM
Compound: 1-Naphthol
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
[PMID: 30199251]
RBL-1 IC50
3.6 μM
Compound: 1
Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
[PMID: 2104936]
In Vitro

The ESPT kinetics of 1-Naphthol are sensitive to the availability of proton-accepting waters around the probe microenvironment, which is reflected in the fluorescence decay kinetics of the different protonated forms of the probe. The fluorescence lifetimes of excited anionic and neutral forms of 1-Naphthol allow for direct monitoring of the hydration level in the microenvironment[1].
1-Naphthol is distributed in all domains of the system: bulk aqueous phase, interfaces, and hydrophobic dry core, and the probe can fully sense all domains. In addition to the usual fluorescence intensity and spectral shifts, the lifetime parameter set of the two protonated forms also plays an important role[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Naphthol Related Antibodies
Molecular Weight

144.17

Formula

C10H8O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C2C=CC=CC2=CC=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (693.61 mM; Need ultrasonic)

H2O : 1 mg/mL (6.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.9361 mL 34.6806 mL 69.3611 mL
5 mM 1.3872 mL 6.9361 mL 13.8722 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / Ethanol 1 mM 6.9361 mL 34.6806 mL 69.3611 mL 173.4028 mL
5 mM 1.3872 mL 6.9361 mL 13.8722 mL 34.6806 mL
Ethanol 10 mM 0.6936 mL 3.4681 mL 6.9361 mL 17.3403 mL
15 mM 0.4624 mL 2.3120 mL 4.6241 mL 11.5602 mL
20 mM 0.3468 mL 1.7340 mL 3.4681 mL 8.6701 mL
25 mM 0.2774 mL 1.3872 mL 2.7744 mL 6.9361 mL
30 mM 0.2312 mL 1.1560 mL 2.3120 mL 5.7801 mL
40 mM 0.1734 mL 0.8670 mL 1.7340 mL 4.3351 mL
50 mM 0.1387 mL 0.6936 mL 1.3872 mL 3.4681 mL
60 mM 0.1156 mL 0.5780 mL 1.1560 mL 2.8900 mL
80 mM 0.0867 mL 0.4335 mL 0.8670 mL 2.1675 mL
100 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7340 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Naphthol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Naphthol90-15-3Furro ER NSC 9586 Nako TRBNSC9586NSC 9586NSC-9586Endogenous MetaboliteInhibitorinhibitorinhibit

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