2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 1-Naphthol

1-Naphthol  (Synonyms: Furro ER; NSC 9586; Nako TRB)

Cat. No.: HY-Y1309 Purity: 99.83%
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1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.

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1-Naphthol Chemical Structure

1-Naphthol Chemical Structure

CAS No. : 90-15-3

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5 g USD 60 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 1-Naphthol:

1-Naphthol Related Antibodies

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Description

1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
240 μM
Compound: 1-Naphthol
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
[PMID: 21030469]
HEK293 IC50
280 μM
Compound: 1-Naphthol
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
[PMID: 21030469]
K562 IC50
> 100 μM
Compound: 1-Naphthol
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
[PMID: 30199251]
RBL-1 IC50
3.6 μM
Compound: 1
Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
[PMID: 2104936]
Molecular Weight

144.17

Formula

C10H8O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C2C=CC=CC2=CC=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (693.63 mM; Need ultrasonic)

H2O : 1 mg/mL (6.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.9363 mL 34.6813 mL 69.3626 mL
5 mM 1.3873 mL 6.9363 mL 13.8725 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / Ethanol 1 mM 6.9363 mL 34.6813 mL 69.3626 mL 173.4064 mL
5 mM 1.3873 mL 6.9363 mL 13.8725 mL 34.6813 mL
Ethanol 10 mM 0.6936 mL 3.4681 mL 6.9363 mL 17.3406 mL
15 mM 0.4624 mL 2.3121 mL 4.6242 mL 11.5604 mL
20 mM 0.3468 mL 1.7341 mL 3.4681 mL 8.6703 mL
25 mM 0.2775 mL 1.3873 mL 2.7745 mL 6.9363 mL
30 mM 0.2312 mL 1.1560 mL 2.3121 mL 5.7802 mL
40 mM 0.1734 mL 0.8670 mL 1.7341 mL 4.3352 mL
50 mM 0.1387 mL 0.6936 mL 1.3873 mL 3.4681 mL
60 mM 0.1156 mL 0.5780 mL 1.1560 mL 2.8901 mL
80 mM 0.0867 mL 0.4335 mL 0.8670 mL 2.1676 mL
100 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7341 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Naphthol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Naphthol90-15-3Furro ER NSC 9586 Nako TRBNSC9586NSC 9586NSC-9586Endogenous MetaboliteInhibitorinhibitorinhibit

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