1-Methyl-L-histidine-d₃

Name: 1-Methyl-L-histidine-d 3
Brand: MedChemExpress
SKU: HY-W017006S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W017006S Purity: 99.40%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-Methyl-L-histidine-d₃ is the deuterium labeled 1-Methyl-L-histidine. 1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

For research use only. We do not sell to patients.

1-Methyl-L-histidine-d<sub>3</sub> Chemical Structure

1-Methyl-L-histidine-d₃ Chemical Structure

CAS No. : 91037-48-8

Size	Price	Stock	Quantity
1 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 1-Methyl-L-histidine-d₃:

1-Methyl-L-histidine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

1-Methyl-L-histidine-d₃ is the deuterium labeled 1-Methyl-L-histidine. 1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

172.20

Formula

C₇H₈D₃N₃O₂

CAS No.

91037-48-8

Unlabeled CAS

332-80-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC([C@@H](N)CC1=CN(C([2H])([2H])[2H])C=N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (725.90 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8072 mL	29.0360 mL	58.0720 mL
5 mM	1.1614 mL	5.8072 mL	11.6144 mL
10 mM	0.5807 mL	2.9036 mL	5.8072 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.40%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (247 KB) HNMR (253 KB) RP-HPLC (703 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O	1 mM	5.8072 mL	29.0360 mL	58.0720 mL	145.1800 mL
	5 mM	1.1614 mL	5.8072 mL	11.6144 mL	29.0360 mL
	10 mM	0.5807 mL	2.9036 mL	5.8072 mL	14.5180 mL
	15 mM	0.3871 mL	1.9357 mL	3.8715 mL	9.6787 mL
	20 mM	0.2904 mL	1.4518 mL	2.9036 mL	7.2590 mL
	25 mM	0.2323 mL	1.1614 mL	2.3229 mL	5.8072 mL
	30 mM	0.1936 mL	0.9679 mL	1.9357 mL	4.8393 mL
	40 mM	0.1452 mL	0.7259 mL	1.4518 mL	3.6295 mL
	50 mM	0.1161 mL	0.5807 mL	1.1614 mL	2.9036 mL
	60 mM	0.0968 mL	0.4839 mL	0.9679 mL	2.4197 mL
	80 mM	0.0726 mL	0.3630 mL	0.7259 mL	1.8148 mL
	100 mM	0.0581 mL	0.2904 mL	0.5807 mL	1.4518 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.