1-Oxomiltirone

Cat. No.: HY-N10703: FAQs
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2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4,5(6H)-trione is a C₂₀ -norabietane diterpenoid with anti-inflammatory activity. 2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4,5(6H)-trione can be isolated from sage leaves.

For research use only. We do not sell to patients.

1-Oxomiltirone Chemical Structure

CAS No. : 142546-16-5

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	24.89 μM Compound: 19	Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
BXPC-3	GI₅₀	20.54 μM Compound: 19	Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	GI₅₀	23.27 μM Compound: 19	Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
KB 3-1	IC₅₀	46.6 μM Compound: 4	Cytotoxicity against drug-sensitive human KB-3-1 cells after 48 hrs by MTS/PMS assay Cytotoxicity against drug-sensitive human KB-3-1 cells after 48 hrs by MTS/PMS assay	[PMID: 11720520]
KB-V1	IC₅₀	47.8 μM Compound: 4	Cytotoxicity against multidrug-resistant human KBV1 cells after 48 hrs by MTS/PMS assay Cytotoxicity against multidrug-resistant human KBV1 cells after 48 hrs by MTS/PMS assay	[PMID: 11720520]
MIA PaCa-2	IC₅₀	29.9 μM Compound: 18	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 21775156]
MRC5	GI₅₀	20.39 μM Compound: 19	Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PANC-1	GI₅₀	32.15 μM Compound: 19	Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PC-3	GI₅₀	18.97 μM Compound: 19	Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]

In Vitro

2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4,5(6H)-trione (compound 12) has inhibitory effects on LPS-stimulated NO production in RAW264.7 cells with an IC₅₀ value of 5.86 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

296.36

Formula

C₁₉H₂₀O₃

CAS No.

142546-16-5

SMILES

O=C1C(C(C(C)C)=CC2=C1C(C(CCC3(C)C)=O)=C3C=C2)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lingnan Li, et al. Anti-inflammatory norabietane diterpenoids from the leaves of Salvia officinalis L. Journal of Functional Foods 54 (2019) 154-163.

1-Oxomiltirone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Oxomiltirone142546-16-5OthersC20-norabietanediterpenoidanti-inflammatorysage leavesInhibitorinhibitorinhibit

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