2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. 1-Piperazinehexanoic acid-thalidomide

1-Piperazinehexanoic acid-thalidomide 

Cat. No.: HY-162737 Purity: 98.30%
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1-Piperazinehexanoic acid-thalidomide is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete JMV7048 (HY-162704).

For research use only. We do not sell to patients.

1-Piperazinehexanoic acid-thalidomide Chemical Structure

1-Piperazinehexanoic acid-thalidomide Chemical Structure

CAS No. : 2819682-33-0

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1-Piperazinehexanoic acid-thalidomide Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

1-Piperazinehexanoic acid-thalidomide is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete JMV7048 (HY-162704)[1].

Molecular Weight

456.49

Formula

C23H28N4O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCCCCN1CCN(C2=CC=C(C(N(C3CCC(NC3=O)=O)C4=O)=O)C4=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1906 mL 10.9531 mL 21.9063 mL
5 mM 0.4381 mL 2.1906 mL 4.3813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1906 mL 10.9531 mL 21.9063 mL 54.7657 mL
5 mM 0.4381 mL 2.1906 mL 4.3813 mL 10.9531 mL
10 mM 0.2191 mL 1.0953 mL 2.1906 mL 5.4766 mL
15 mM 0.1460 mL 0.7302 mL 1.4604 mL 3.6510 mL
20 mM 0.1095 mL 0.5477 mL 1.0953 mL 2.7383 mL
25 mM 0.0876 mL 0.4381 mL 0.8763 mL 2.1906 mL
30 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8255 mL
40 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3691 mL
50 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
60 mM 0.0365 mL 0.1826 mL 0.3651 mL 0.9128 mL
80 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6846 mL
100 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5477 mL
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1-Piperazinehexanoic acid-thalidomide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Piperazinehexanoic acid-thalidomide2819682-33-0E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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