10-Formyltetrahydrofolic acid

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10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (10-Formyltetrahydrofolic acid disodium) usually boasts enhanced water solubility and stability.

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10-Formyltetrahydrofolic acid Chemical Structure

CAS No. : 2800-34-2

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Other Forms of 10-Formyltetrahydrofolic acid:

10-Formyltetrahydrofolic acid disodium Get quote

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Description	10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines^[1].
In Vivo	10-Formyltetrahydrofolic acid in the liver of male Sprague-Dawley rats increases significantly after 30 and 60 minutes by administration of 1.3 mmol/kg methionine^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	473.44
Formula	C₂₀H₂₃N₇O₇
CAS No.	2800-34-2
SMILES	O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2NC3=C(N=C(N)NC3=O)NC2)C=O)C=C1)=O
Structure Classification	Others
Initial Source	Endogenous metabolite
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Donald W Horne, et al. Neither methionine nor nitrous oxide inactivation of methionine synthase affect the concentration of 5,10-methylenetetrahydrofolate in rat liver. J Nutr. 2003 Feb;133(2):476-8. [Content Brief]