2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel GABA Receptor
  4. 12,14-Dichlorodehydroabietic acid

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release.

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12,14-Dichlorodehydroabietic acid Chemical Structure

12,14-Dichlorodehydroabietic acid Chemical Structure

CAS No. : 65281-77-8

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12,14-Dichlorodehydroabietic acid Related Antibodies

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Description

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].

IC50 & Target

Ca2+-activated K+ (BK) channel[2]
GABAA[1]
Molecular Weight

369.33

Formula

C20H26Cl2O2
CAS No.
SMILES

O=C([C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O
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12,14-Dichlorodehydroabietic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12,14-Dichlorodehydroabietic acid65281-77-8Potassium ChannelGABA ReceptorKcsAGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorChlorinatedresinacidCa2+transmitterGABAABKα,Inhibitorinhibitorinhibit

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