1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Potassium Channel GABA Receptor
  3. 12,14-Dichlorodehydroabietic acid

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release.

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12,14-Dichlorodehydroabietic acid Chemical Structure

12,14-Dichlorodehydroabietic acid Chemical Structure

CAS No. : 65281-77-8

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Description

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].

IC50 & Target

Ca2+-activated K+ (BK) channel[2]
GABAA[1]

Molecular Weight

369.33

Formula

C20H26Cl2O2

CAS No.
SMILES

O=C([C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O

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Product Name:
12,14-Dichlorodehydroabietic acid
Cat. No.:
HY-133596
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