2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 12-Hydroxynevirapine

12-Hydroxynevirapine  (Synonyms: 12-hydroxy-NVP; 12-OH-NVP)

Cat. No.: HY-148642
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12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine.

For research use only. We do not sell to patients.

12-Hydroxynevirapine Chemical Structure

12-Hydroxynevirapine Chemical Structure

CAS No. : 133627-24-4

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Based on 1 publication(s) in Google Scholar

12-Hydroxynevirapine Related Antibodies

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Description

12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine[1][2].

Molecular Weight

282.30

Formula

C15H14N4O2
CAS No.
SMILES

O=C1NC2=C(CO)C=CN=C2N(C3CC3)C4=NC=CC=C14
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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12-Hydroxynevirapine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12-Hydroxynevirapine133627-24-412-hydroxy-NVP 12-OH-NVPDrug Metaboliteoxidative metabolitenon-nucleosidereverse transcriptaseHIV-1infectionidiosyncratic hepatotoxicitymild-to-severe skin rashessulphotransferasesSULTs12-Sulphoxy-nevirapineInhibitorinhibitorinhibit

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