2. Anti-infection
  3. HIV
  4. 12-Oxocalanolide A

12-Oxocalanolide A  (Synonyms: (±)-12-Oxocalanolide A)

Cat. No.: HY-N1034
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12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC50 and EC50 of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide.

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12-Oxocalanolide A Chemical Structure

12-Oxocalanolide A Chemical Structure

CAS No. : 161753-49-7

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12-Oxocalanolide A Related Antibodies

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Description

12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC50 and EC50 of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide[1].

IC50 & Target

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
CEM-SS EC50
0.15 μM
Compound: 10
Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
[PMID: 8893846]
CEM-SS EC50
1.2 μM
Compound: (+/-)5
Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
[PMID: 9083491]
CEM-SS IC50
19 μM
Compound: (+/-)5
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
[PMID: 9083491]
CEM-SS IC50
9.3 μM
Compound: 10
Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
[PMID: 8893846]
Molecular Weight

368.42

Formula

C22H24O5
CAS No.
SMILES

O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C4C(C([C@H](C)[C@@H](C)O4)=O)=C2O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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12-Oxocalanolide A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12-Oxocalanolide A161753-49-7(±)-12-Oxocalanolide AHIVHuman immunodeficiency virusreverse transcriptaseHIV-1CalanolideInhibitorinhibitorinhibit

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