2. MAPK/ERK Pathway Cell Cycle/DNA Damage Stem Cell/Wnt
  3. p38 MAPK DNA/RNA Synthesis ERK
  4. 12(S)-HETE

12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells.

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12(S)-HETE Chemical Structure

12(S)-HETE Chemical Structure

CAS No. : 54397-83-0

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Solvent
100 μg (312.04 μM * 1 mL in Ethanol) USD 940 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 12(S)-HETE:

12(S)-HETE Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

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Description

12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells[1][2].

Molecular Weight

320.47

Formula

C20H32O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

SDS (604 KB)

COA (238 KB)

Handling Instructions (2659 KB)
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12(S)-HETE Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12(S)-HETE54397-83-0p38 MAPKDNA/RNA SynthesisERKExtracellular signal regulated kinasesCancer cell proliferation12-lipoxygenaseInhibitorinhibitorinhibit

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