2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 12R-LOX-IN-1

12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research.

For research use only. We do not sell to patients.

12R-LOX-IN-1 Chemical Structure

12R-LOX-IN-1 Chemical Structure

CAS No. : 857758-13-5

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Description

12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].

Molecular Weight

237.25

Formula

C15H11NO2
CAS No.
SMILES

OC1=CC=C(N=C(C2=CC=CC=C2O)C=C3)C3=C1
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Purity & Documentation
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12R-LOX-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12R-LOX-IN-1857758-13-5DNA/RNA SynthesispsoriatickeratinocytesantipsoriaticKi67Inhibitorinhibitorinhibit

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