12β-Hydroxyresibufogenin

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12β-Hydroxyresibufogenin is a bufadienolide, which shows significant inhibitory activities against cancer cell lines.

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12β-Hydroxyresibufogenin Chemical Structure

CAS No. : 2042-58-2

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Biological Activity
Purity & Documentation
References
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Description

12β-Hydroxyresibufogenin is a bufadienolide, which shows significant inhibitory activities against cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	0.12 μg/mL Compound: 8	Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 11575946]
DU-145	IC₅₀	0.041 μg/mL Compound: 8	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 11575946]
HL-60	IC₅₀	0.045 μg/mL Compound: 8	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 11575946]
KB	IC₅₀	0.97 μg/mL Compound: 8	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 11575946]
KM-20L2	IC₅₀	0.012 μg/mL Compound: 8	Cytotoxicity against human KM20L2 cells after 72 hrs by MTT assay Cytotoxicity against human KM20L2 cells after 72 hrs by MTT assay	[PMID: 11575946]
MCF7	IC₅₀	0.066 μg/mL Compound: 8	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 11575946]
MH60	IC₅₀	> 25 μg/mL Compound: 8	Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay	[PMID: 11575946]
NCI-H460	IC₅₀	0.017 μg/mL Compound: 8	Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay	[PMID: 11575946]
SF-268	IC₅₀	0.046 μg/mL Compound: 8	Cytotoxicity against human SF268 cells after 72 hrs by MTT assay Cytotoxicity against human SF268 cells after 72 hrs by MTT assay	[PMID: 11575946]

Molecular Weight

400.51

Formula

C₂₄H₃₂O₅

CAS No.

2042-58-2

SMILES

C[C@@]12[C@]3([C@](C[C@@H]2C(C=C4)=COC4=O)([H])O3)[C@@]5([H])[C@]([C@@]6([C@](C[C@H](CC6)O)([H])CC5)C)([H])C[C@H]1O

Structure Classification

Others

Initial Source

Animals

Ch’an Su

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nogawa T, et al. Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su. J Nat Prod. 2001 Sep;64(9):1148-52. [Content Brief]