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13-14-dihydro-15-keto-prostaglandin-e1-d4

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Natural
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2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113208
    13,14-Dihydro-15-keto Prostaglandin F2α

    13,14-dihydro-15-keto-PGF2α

    		 Endogenous Metabolite Others
    13,14-Dihydro-15-keto Prostaglandin F2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
    13,14-Dihydro-15-keto Prostaglandin F2α
  • HY-163373
    13,14-Dihydro-15-keto prostaglandin D1

    		Others Endocrinology
    13,14-Dihydro-15-keto prostaglandin D1 is a derivative of prostaglandin D1 .
    13,14-Dihydro-15-keto prostaglandin D1
  • HY-116083
    13,14-Dihydro-15-keto-tetranor prostaglandin D2

    		Endogenous Metabolite Others
    13,14-Dihydro-15-keto-tetranor prostaglandin D2 (Compound VI) is a prostaglandin D2 metabolite. 13,14-Dihydro-15-keto-tetranor prostaglandin D2 as a biomarker can be used to study prostaglandin D2-related diseases .
    13,14-Dihydro-15-keto-tetranor prostaglandin D2
  • HY-118830
    13,14-Dihydro-15-keto prostaglandin D2

    DK-PGD2; 15-Oxo-13,14-dihydro-PGD2; 13,14-dihydro-15-keto-PGD2

    		 Prostaglandin Receptor Endocrinology
    13, 14-Dihydro-15-keto prostaglandin D2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandin D2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandin D2 can inhibit ion flux in canine colonic mucosa preparation .
    13,14-Dihydro-15-keto prostaglandin D2
  • HY-113461
    13,14-Dihydro-15-keto-prostaglandin A2

    		Others Others
    13,14-Dihydro-15-keto-prostaglandin A2 is a product of the non-enzymatic dehydration of 13,14-dihydro-15-keto PGE2. It is further broken down into bicyclo PGE2, which acts as a biomarker for PGE2 synthesis .
    13,14-Dihydro-15-keto-prostaglandin A2
  • HY-113459S1
    13,14-Dihydro-15-keto Prostaglandin F2α-d4

    13,14-dihydro-15-keto-PGF2α-d4

    		 Isotope-Labeled Compounds Prostaglandin Receptor Endocrinology
    13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
    13,14-Dihydro-15-keto Prostaglandin F2α-d4
  • HY-113208A
    11β-13,14-Dihydro-15-keto Prostaglandin F2α

    11β-13,14-dihydro-15-keto PGF2α; 11-epi-13,14-dihydro-15-keto PGF2α

    		 Endogenous Metabolite Others
    11β-13,14-Dihydro-15-keto Prostaglandin F2α is the deviative of 13,14-Dihydro-15-keto PGF2a (HY-113208), which is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
    11β-13,14-Dihydro-15-keto Prostaglandin F2α
  • HY-113208AS1
    11β-13,14-Dihydro-15-keto Prostaglandin F2α-d4

    11β-13,14-dihydro-15-keto PGF2α-d4; 11-epi-13,14-dihydro-15-keto PGF2α-d4

    		 Isotope-Labeled Compounds Others
    11β-13,14-Dihydro-15-keto Prostaglandin F2α-d4 is is the deuterium labeled 11β-13,14-dihydro-15-keto Prostaglandin F2α.
    11β-13,14-Dihydro-15-keto Prostaglandin F2α-d4
  • HY-157925
    Bicyclo-PGE1

    Bicyclo prostaglandin E1

    		 Others Others
    Bicyclo-PGE1 (Bicyclo Prostaglandin E1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo-PGE1 can be used to estimate the biosynthesis and metabolism of PGE1 in vivo .
    Bicyclo-PGE1
  • HY-113778
    15-keto-17-phenyl trinor Prostaglandin F2α

    15-keto-17-phenyl trinor PGF2α

    		 Prostaglandin Receptor Endocrinology
    Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.1 Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.2 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye.
    15-keto-17-phenyl trinor Prostaglandin F2α
  • HY-137504
    20-ethyl Prostaglandin F2α

    ICI 74205; 20-ethyl PGF2α

    		 Prostaglandin Receptor Metabolic Disease
    20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone.noprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2α increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2α (50 nM).2 In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.
    20-ethyl Prostaglandin F2α

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