2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Monoamine Transporter Dopamine Transporter
  4. 13-Hydroxyisobakuchiol

13-Hydroxyisobakuchiol  (Synonyms: Delta3,2-Hydroxylbakuchiol)

Cat. No.: HY-N7506
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Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression.

For research use only. We do not sell to patients.

13-Hydroxyisobakuchiol Chemical Structure

13-Hydroxyisobakuchiol Chemical Structure

CAS No. : 178765-49-6

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13-Hydroxyisobakuchiol Related Antibodies

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Description

Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression[1].

IC50 & Target

IC50: 0.58 μM (dopamine transporter)
IC50: 0.69 μM (norepinephrine transporter)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 19
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 25710081]
K562 IC50
> 10 μM
Compound: 19
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 25710081]
Molecular Weight

272.38

Formula

C18H24O2
CAS No.
SMILES

OC1=CC=C(/C=C/[C@](C)(C=C)C/C=C/C(C)(O)C)C=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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13-Hydroxyisobakuchiol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13-Hydroxyisobakuchiol178765-49-6Delta3,2-HydroxylbakuchiolMonoamine TransporterDopamine TransporterDATSLC6A3monoamine transporterdopamine transporternorepinephrine transporterParkinson's diseasedepressionaddictionInhibitorinhibitorinhibit

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