2. Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. PPAR Endogenous Metabolite
  4. 15-Deoxy-Δ-12,14-prostaglandin J2

15-Deoxy-Δ-12,14-prostaglandin J2  (Synonyms: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2)

Cat. No.: HY-108568 Purity: ≥99.0%
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15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.

For research use only. We do not sell to patients.

15-Deoxy-Δ-12,14-prostaglandin J2 Chemical Structure

15-Deoxy-Δ-12,14-prostaglandin J2 Chemical Structure

CAS No. : 87893-55-8

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1 mg (3.16 mM * 1 mL in Methyl acetate) USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 15-Deoxy-Δ-12,14-prostaglandin J2:

15-Deoxy-Δ-12,14-prostaglandin J2 Related Antibodies

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1 Publications Citing Use of MCE 15-Deoxy-Δ-12,14-prostaglandin J2

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Description

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

IC50 & Target[1]

PPARγ

2 μM (EC50)

PPARδ

 

Human Endogenous Metabolite

 

In Vitro

15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

15-Deoxy-Δ-12,14-prostaglandin J2 Related Antibodies
Molecular Weight

316.43

Formula

C20H28O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

Ethanol : 75 mg/mL (237.02 mM; Need ultrasonic and warming)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.1603 mL 15.8013 mL 31.6026 mL 79.0064 mL
5 mM 0.6321 mL 3.1603 mL 6.3205 mL 15.8013 mL
10 mM 0.3160 mL 1.5801 mL 3.1603 mL 7.9006 mL
15 mM 0.2107 mL 1.0534 mL 2.1068 mL 5.2671 mL
20 mM 0.1580 mL 0.7901 mL 1.5801 mL 3.9503 mL
25 mM 0.1264 mL 0.6321 mL 1.2641 mL 3.1603 mL
30 mM 0.1053 mL 0.5267 mL 1.0534 mL 2.6335 mL
40 mM 0.0790 mL 0.3950 mL 0.7901 mL 1.9752 mL
50 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5801 mL
60 mM 0.0527 mL 0.2634 mL 0.5267 mL 1.3168 mL
80 mM 0.0395 mL 0.1975 mL 0.3950 mL 0.9876 mL
100 mM 0.0316 mL 0.1580 mL 0.3160 mL 0.7901 mL
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15-Deoxy-Δ-12,14-prostaglandin J2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-Deoxy-Δ-12,14-prostaglandin J287893-55-815d-PGJ2 15-Deoxy-Δ12,14-PGJ2PPAREndogenous MetabolitePeroxisome proliferator-activated receptorsEnonePPARγPPARδcyclopentenoneprostaglandincovalentCys249Inhibitorinhibitorinhibit

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