15(S)-Latanoprost (Synonyms: 15-epi Latanoprost)

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15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC₅₀ values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.

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15(S)-Latanoprost Chemical Structure

CAS No. : 145773-22-4

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Description	15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC₅₀ values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
Molecular Weight	432.59
Formula	C₂₆H₄₀O₅
CAS No.	145773-22-4
SMILES	O[C@@H]1[C@@H]([C@H]([C@@H](C1)O)CC[C@@H](CCC2=CC=CC=C2)O)C/C=C\CCCC(OC(C)C)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Resul, et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. J. Med. Chem. 36(2), 243-248 (1993).

15(S)-Latanoprost Related Classifications

Cardiovascular Disease Others

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15(S)-Latanoprost145773-22-415-epi LatanoprostOthersInhibitorinhibitorinhibit

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15(S)-Latanoprost (Synonyms: 15-epi Latanoprost)

Other Forms of 15(S)-Latanoprost:

15(S)-Latanoprost Related Antibodies

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Biological Activity

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