16(R)-AFP 07 free acid

Cat. No.: HY-129922: FAQs
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Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.

For research use only. We do not sell to patients.

16(R)-AFP 07 free acid Chemical Structure

CAS No. : 773825-80-2

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DP EP FP IP TXA₂/TP TXB₂

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Description	Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.
Molecular Weight	412.47
Formula	C₂₂H₃₀F₂O₅
CAS No.	773825-80-2
SMILES	O=C(O)CCC/C=C1C(F)(F)[C@@]([C@@H](/C=C/[C@H](O)[C@@H](C)CC#CCC)[C@H](O)C2)([H])[C@@]2([H])O/1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Chang, et al. 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor. Prostaglandins 53(2), 83-90 (1997).