17-trifluoromethylphenyl trinor Prostaglandin F2α  (Synonyms: 17-Trifluoromethylphenyl trinor PGF2α)

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.

456.50

C₂₄H₃₁F₃O₅

221246-34-0

O[C@@H]1[C@@H]([C@H]([C@@H](C1)O)/C=C/[C@H](CCC2=CC(C(F)(F)F)=CC=C2)O)C/C=C\CCCC(O)=O

Room temperature in continental US; may vary elsewhere.

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• [1]. Sorbera, et al. Travoprost. Drugs Future 25(1), 41-45 (2000).