17β-HSD1-IN-2

Cat. No.: HY-129433: FAQs
Data Sheet Handling Instructions

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17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (K_i=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders.

For research use only. We do not sell to patients.

17β-HSD1-IN-2 Chemical Structure

CAS No. : 1318265-18-7

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Description

IC₅₀ & Target

17β-HSD1^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
T47D	IC₅₀	68 nM Compound: 23b	Inhibition of 17-beta HSD1 in human T47D cells assessed as transformation of [14C]E1 to [14C]E2 after 24 hrs by thin layer chromatography Inhibition of 17-beta HSD1 in human T47D cells assessed as transformation of [14C]E1 to [14C]E2 after 24 hrs by thin layer chromatography	[PMID: 24328103]
T47D	IC₅₀	68 nM Compound: 5	Inhibition of 17beta-HSD1 in human T47D cells assessed as decrease in transformation of [14C]estrone to [14C]-estradiol after 24 hrs by thin layer chromatography Inhibition of 17beta-HSD1 in human T47D cells assessed as decrease in transformation of [14C]estrone to [14C]-estradiol after 24 hrs by thin layer chromatography	[PMID: 21927646]

Molecular Weight

496.48

Formula

C₂₈H₃₄BrNO₂

CAS No.

1318265-18-7

SMILES

O=C(N)C1=CC=CC(C[C@H]2C[C@@]3([H])[C@]4([H])CCC5=C(C=CC(CCBr)=C5)[C@@]4([H])CC[C@]3(C)[C@H]2O)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Trottier A, et al. Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Biochem Pharmacol. 2017 Nov 15;144:149-161. [Content Brief]

17β-HSD1-IN-2 Related Classifications

Endocrinology

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17β-HSD1-IN-21318265-18-7Othersnon-estrogenicsteroidal covalentestrogen-dependentInhibitorinhibitorinhibit

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