2. Natural Products
  3. Plants Terpenoids
  4. Compositae Labiatae Diterpenoids
  5. Ambrosia camphorata (Greene) W.W.Payne
  6. (19R)-13-Deoxy-19-hydroxyenmein

(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC50 values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively.

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(19R)-13-Deoxy-19-hydroxyenmein Chemical Structure

(19R)-13-Deoxy-19-hydroxyenmein Chemical Structure

CAS No. : 16763-48-7

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(19R)-13-Deoxy-19-hydroxyenmein Related Antibodies

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Description

(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC50 values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
50.86 μM
Compound: 2
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 22483090]
Bel-7402 IC50
32.09 μM
Compound: 2
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
[PMID: 29407983]
Bel-7402 IC50
32.96 μM
Compound: 10
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
[PMID: 23644204]
Bel-7402 IC50
32.96 μM
Compound: 2
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
[PMID: 22483090]
Bel7402/5-FU IC50
44.27 μM
Compound: 2
Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay
[PMID: 29407983]
HeLa IC50
60.7 μM
Compound: 2
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 22483090]
HL-60 IC50
28.07 μM
Compound: 2
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
[PMID: 29407983]
K562 IC50
8.11 μM
Compound: 10
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 23644204]
K562 IC50
8.11 μM
Compound: 2
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 22483090]
L02 IC50
27.06 μM
Compound: 2
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
[PMID: 29407983]
MCF7 IC50
68.2 μM
Compound: 2
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 22483090]
MGC-803 IC50
14.21 μM
Compound: 10
Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay
Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay
[PMID: 23644204]
PC-3 IC50
30.55 μM
Compound: 2
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 29407983]
Molecular Weight

362.42

Formula

C20H26O6
CAS No.
SMILES

O[C@H]1[C@@](C2(C)C)([H])[C@]([C@@](CC2)([H])OC3=O)(CO1)[C@@](CC[C@@]4([H])C5=C)([H])[C@]3(C5=O)C4O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(19R)-13-Deoxy-19-hydroxyenmein Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(19R)-13-Deoxy-19-hydroxyenmein16763-48-7OthersNatural ProductsInhibitorinhibitorinhibit

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