2',3'-cGAMP-C2-PPA 

2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases^[1][2][3].

STING^[1]

850.71

C₂₇H₃₆N₁₀O₁₄P₂S₂

2586047-11-0

OC(CCC(C)SSCC[C@H]1[C@]2([H])[C@@](N3C4=C(C(N=C(N4)N)=O)N=C3)([H])O[C@]1([H])COP(O)(O[C@]5([H])[C@@](O[C@](N6C7=NC=NC(N)=C7N=C6)([H])[C@@H]5O)([H])COP(O)(O2)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen Z, et, al. Antibody-sting agonist conjugates and their use in immunotherapy. US20210015941A1.

  [2]. Stazzoni S, et al. Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202207175.  [Content Brief]

  [3]. Zhang X, et al GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35  [Content Brief]