2,3-Diphosphoglyceric acid  (Synonyms: 2,3-DPG)

2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD)^[1][2][3][4].

2, 3-diphosphoglyceric acid (8 mM, 48 h) inhibits the development of Plasmodium falciparum^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

266.04

C₃H₈O₁₀P₂

138-81-8

O=C(O)C(OP(O)(O)=O)COP(O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shakil H. Merchant MD, et al. 24 - Molecular Diagnosis in Hematopathology. Hematopathology (Second Edition).2012, 679-726.

  [2]. Płoszczyca K, et al. Red Blood Cell 2,3-Diphosphoglycerate Decreases in Response to a 30 km Time Trial Under Hypoxia in Cyclists. Front Physiol. 2021 Jun 15;12:670977.  [Content Brief]

  [3]. Morais I, et al. Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro. Front Cell Infect Microbiol. 2022 Mar 15;12:840968.  [Content Brief]

  [4]. Kosenko EA, et al. Relationship between chronic disturbance of 2,3-diphosphoglycerate metabolism in erythrocytes and Alzheimer disease. CNS Neurol Disord Drug Targets. 2016;15(1):113-23.  [Content Brief]