2. Anti-infection
  3. Parasite
  4. 2',6'-Dihydroxy-4'-methoxydihydrochalcone

2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro.

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2',6'-Dihydroxy-4'-methoxydihydrochalcone Chemical Structure

2',6'-Dihydroxy-4'-methoxydihydrochalcone Chemical Structure

CAS No. : 35241-55-5

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2',6'-Dihydroxy-4'-methoxydihydrochalcone Related Antibodies

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Description

2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro[1][2].

Cellular Effect
Cell Line Type Value Description References
B16-F10 IC50
373 μM
Compound: 5
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay
[PMID: 27720556]
KB ED50
> 10 μg/mL
Compound: 1
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 8158163]
NCI-H187 IC50
9.7 μM
Compound: 1b
Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay
Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay
[PMID: 20362442]
Molecular Weight

272.30

Formula

C16H16O4
CAS No.
SMILES

O=C(C1=C(O)C=C(OC)C=C1O)CCC2=CC=CC=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2',6'-Dihydroxy-4'-methoxydihydrochalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2',6'-Dihydroxy-4'-methoxydihydrochalcone35241-55-5ParasiteInhibitorinhibitorinhibit

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