2. Immunology/Inflammation
  3. NO Synthase
  4. 2′-Hydroxy-2,3-dimethoxychalcone

α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells.

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2′-Hydroxy-2,3-dimethoxychalcone Chemical Structure

2′-Hydroxy-2,3-dimethoxychalcone Chemical Structure

CAS No. : 42220-80-4

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2′-Hydroxy-2,3-dimethoxychalcone Related Antibodies

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Description

α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells[1].

Cellular Effect
Cell Line Type Value Description References
A2780cisR GI50
14.38 μM
Compound: 4
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
[PMID: 24565968]
RAW264.7 IC50
3.8 μM
Compound: 15
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay
[PMID: 19233646]
Molecular Weight

284.31

Formula

C17H16O4
CAS No.
SMILES

O=C(C1=C(O)C=CC=C1)/C=C/C2=C(OC)C(OC)=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2′-Hydroxy-2,3-dimethoxychalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2′-Hydroxy-2,3-dimethoxychalcone42220-80-4NO SynthaseNitric oxide synthasesNOSDerivativesAnti-inflammatory activityLPSNitric oxide synthaseRAW 264.7Inhibitorinhibitorinhibit

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