2. Metabolic Enzyme/Protease
  3. Proteasome
  4. 20S Proteasome-IN-3

20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM). 20S Proteasome-IN-3 shows anti-tumor proliferation activity.

For research use only. We do not sell to patients.

20S Proteasome-IN-3 Chemical Structure

20S Proteasome-IN-3 Chemical Structure

CAS No. : 1803040-07-4

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20S Proteasome-IN-3 Related Antibodies

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Description

20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM)[1][2]. 20S Proteasome-IN-3 shows anti-tumor proliferation activity[2].

IC50 & Target

IC50: 1.64 μM (20S proteasome β5 subunit)[1]
In Vitro

20S Proteasome-IN-3 (Compound 10b) (5.34-9.69 μM, 18-24 h) exhibits significant inhibition against A375, SW480, DU145, and HeLa cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

20S Proteasome-IN-3 Related Antibodies

Cell Proliferation Assay[2]

Cell Line: A375, SW480, DU145, and HeLa cell lines
Concentration: 5.34-9.69 μM
Incubation Time: 18-24 hours
Result: Inhibited the proliferation of SW480, DU145, A375 and HeLa cells with the IC50s of 5.34, 9.69, 5.66 and 7.03 μM, respectively.
Molecular Weight

621.72

Formula

C34H43N3O8
CAS No.
SMILES

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(C2=CC=CO2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CC=C(C=C3)OC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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20S Proteasome-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

20S Proteasome-IN-31803040-07-4ProteasomeA375SW480DU145HeLa20S proteasomeanti-tumor proliferationInhibitorinhibitorinhibit

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